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BPC-157 + TB-500 (Wolverine)

cGMP Manufacturing

All Instrips products are manufactured in cGMP-compliant facilities with strict adherence to quality standards. Full chain-of-custody documentation ensures traceability, reliability, and reproducibility for research purposes.

Research Applications

Designed for precision research, these peptides support a wide range of experimental protocols. Ideal for laboratory studies requiring consistent, reproducible compound delivery.

Safety & Compliance

All products are intended for research use only. Follow standard lab safety guidelines, including proper protective equipment and waste disposal protocols.

BPC-157 + TB-500 (often referred to as the Wolverine Stack or Blend) is a research combination of two synthetic peptides known for their complementary tissue repair and regenerative properties.

BPC-157 (Body Protection Compound-157) is a pentadecapeptide derived from a gastric protein, studied for its role in promoting angiogenesis, modulating inflammation, supporting gastrointestinal integrity, and accelerating healing of tendons, ligaments, muscles, and other tissues.

TB-500 (Thymosin Beta-4 fragment) is a synthetic peptide that regulates actin polymerization, cell migration, and wound healing, researched for its systemic effects on tissue repair, flexibility, and recovery from injury.

When combined, these peptides are studied for potential synergistic effects that may enhance overall recovery, reduce inflammation, and support comprehensive healing across multiple tissue types in research models.

Key Research Areas:

  • Tissue repair and regeneration (tendons, ligaments, muscles)
  • Wound healing and injury recovery
  • Anti-inflammatory and protective effects
  • Gastrointestinal and vascular health
  • Systemic recovery and performance models.

Compound Information๐Ÿงช

Technical specifications

BPC-157 Profile

Body Protection Compound-157

Type Synthetic pentadecapeptide
CAS Number 137525-51-0
Molecular Weight1,419.5 g/mol
Amino Acids 15
Sequence GEPPPGKPADDAGLV
Origin Human gastric juice

PubChem Database

TB-500 Profile

Thymosin Beta-4 (Fragment)

Type Synthetic/endogenous peptide
CAS Number 77591-33-4
Molecular Weight 4,963 Da
Amino Acids 43
Active Region 17LKKTET22 (actin binding)
OriginThymus, platelets

Expert Opin Biol Ther (2012)

๐Ÿ“šSources & References

HSS Journal (NIH/PubMed Central)

HSS Journal (NIH/PubMed Central)

Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review

2025โ€ขDOI:ย 10.1177/15563316251355551โ€ขPMID:ย 40756949

Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, Apostolakos JM

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Expert Opinion on Biological Therapy

Expert Opinion on Biological Therapy

Thymosin ฮฒ4: a multi-functional regenerative peptide. Basic properties and clinical applications

2012โ€ขDOI:ย 10.1517/14712598.2012.634793โ€ขPMID:ย 22074294

Goldstein AL, Hannappel E, Sosne G, Kleinman HK

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Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences

A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers

2010โ€ขDOI:ย 10.1111/j.1749-6632.2010.05474.xโ€ขPMID:ย 20536472

Ruff D, Crockford D, Girardi G, Zhang Y

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Annals of the New York Academy of Sciences

Journal of Investigative Dermatology

Thymosin beta4 accelerates wound healing

1999โ€ขDOI:ย 10.1046/j.1523-1747.1999.00708.xโ€ขPMID:ย 10469335

Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK

View Source
Journal of Applied Physiology

Journal of Applied Physiology

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration

2011โ€ขDOI:ย 10.1152/japplphysiol.00945.2010โ€ขPMID:ย 21030672

Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH

View Source
Scientific Reports (Nature)

Scientific Reports (Nature)

Modulatory effects of BPC 157 on vasomotor tone and the Src-Cav-1-eNOS signaling pathway in rats

2020โ€ขDOI:ย 10.1038/s41598-020-74022-yโ€ขPMID:ย 33046803

Hsieh MJ, Lee CH, Chueh HY, et al.

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Regulatory Toxicology and Pharmacology

Regulatory Toxicology and Pharmacology

Preclinical safety evaluation of body protective compound-157, a potential drug for treating various wounds

2020โ€ขDOI:ย 10.1016/j.yrtph.2020.104665โ€ขPMID:ย 32334036

Xu C, Sun L, Ren F, et al.

View Source
Nature

Nature

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

2004โ€ขDOI:ย 10.1038/nature03000โ€ขPMID:ย 15565145

Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D

View Source
Growth Hormone & IGF Research

Growth Hormone & IGF Research

BPC-157 enhances growth hormone receptor expression in injured tendon tissue

2018โ€ขDOI:ย 10.1016/j.ghir.2018.02.001

Staresinic M, Sebecic B, et al.

View Source
International Journal of Molecular Sciences (PMC)

International Journal of Molecular Sciences (PMC)

Progress on the Function and Application of Thymosin ฮฒ4

2021โ€ขDOI:ย 10.3390/ijms222413136

Xing Y, et al.

View Source
ClinicalTrials.gov

ClinicalTrials.gov

PCO-02 - Safety and Pharmacokinetics Trial (Phase 1)

2015
View Source
GlobalRPH Clinical Review

GlobalRPH Clinical Review

BPC-157 and TB-500: Background, Indications, Efficacy, and Safety

2025

McAuley D

View Source

โš ๏ธImportant Research Notice

Not for human consumption.ย This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

Weight.4 oz
Dimensions.6 × .6 × 1.4 in
Size10mg, 20mg

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All products offered on our website are accompanied by a Certificate of Analysis (COA) to ensure quality, purity, and consistency for research purposes.

Each batch undergoes rigorous analytical testing performed by qualified laboratories using validated methods such as High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). These tests verify the identity, purity, and composition of the product.

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