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5-Amino-1MQ

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Research Applications

Designed for precision research, these peptides support a wide range of experimental protocols. Ideal for laboratory studies requiring consistent, reproducible compound delivery.

Safety & Compliance

All products are intended for research use only. Follow standard lab safety guidelines, including proper protective equipment and waste disposal protocols.

 

5-Amino-1MQ  A selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) that modulates NAD+ salvage and lipogenesis pathways in preclinical metabolic research models. Premium Research Peptide.
 

Compound Information🧪

Molecular Profile

What Is 5-Amino-1MQ?

Type Small molecule NNMT inhibitor
CAS Number 42464-96-0
Molecular Weight 159.21 g/mol (cation)
Salt Form 286.11 g/mol (iodide salt)
Formula C₁₀H₁₁N₂⁺ (cation)
Appearance Brown to reddish-brown solid

PubChem / J. Med. Chem. 2017

Stability Information

Soluble in DMSO
Avoid repeated freeze-thaw
Aliquot after reconstitution
❄️Lyophilized (powder)
-20°C•stable 24+ months
💉Short-term storage
2-8°C•up to 30 days
💉Reconstituted
2-8°C•use within 7-14 days

📚Sources & References

Journal of Medicinal Chemistry

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

2017•DOI: 10.1021/acs.jmedchem.7b00389•PMID: 28548833

Neelakantan H, Wang HY, Vance V et

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Biochemical Pharmacology

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

2018•DOI: 10.1016/j.bcp.2017.11.007•PMID: 29155147

Neelakantan H, Vance V, Wetzel MD et al.

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Biochemical Pharmacology

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

2019•DOI: 10.1016/j.bcp.2019.02.008•PMID: 30753815

Neelakantan H, Brightwell CR, Graber TG et al.

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Scientific Reports

Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

2021•DOI: 10.1038/s41598-021-85051-6•PMID: 33707534

Sampson CM, Dimet AL, Neelakantan H et al.

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Journal of Pharmaceutical and Biomedical Analysis

Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies

2021•DOI: 10.1016/j.jpba.2021.114255•PMID: 34304009

Awosemo O, Neelakantan H, Watowich S et al.

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Journal of Obstetrics and Gynaecology

Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells

2021•DOI: 10.1080/01443615.2020.1854696•PMID: 33645410

Akar S, Duran T, Azzawri AA et al.

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Scientific Reports

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice

2022•DOI: 10.1038/s41598-021-03670-5•PMID: 35013352

Dimet-Wiley A, Wu Q, Wiley JT et al.

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Diabetes, Obesity and Metabolism

Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction

2024•DOI: 10.1111/dom.15879•PMID: 39161060

Babula JJ, Bui D, Stevenson HL et al.

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⚠️Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

Weight.4 oz
Dimensions.6 × .6 × 1.4 in
Size10mg, 40mg

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