Molecular Profile
What Is TB-500?
Expert Opin Biol Ther (2012)
- Type
- Endogenous peptide/synthetic analog
- CAS Number
- 77591-33-4
- Molecular Weight
- 4,963 Da
- Amino Acids
- 43
- Active Region
- Ac-SDKP (N-terminal)
- Key Sequence
- 17LKKTET22 (actin binding)
Research Peptides
TB-500
≥99% purityLyophilized powderThird-party COA
TB-500 is supplied as a sterile lyophilized powder in a sealed glass vial, manufactured to ≥99% purity. Every batch is verified by independent third-party analysis and ships with a Certificate of Analysis.
$39.99
1
- ✓ Same-day dispatch
- ✓ Discreet packaging
- ✓ Third-party tested batch
- ✓ COA available
Certificate of analysis
TB-500 is supplied as a sterile lyophilized powder in a sealed glass vial, manufactured to ≥99% purity. Every batch is verified by independent third-party analysis and ships with a Certificate of Analysis.
⚠ Research use only. This product is intended solely for in-vitro laboratory research by qualified professionals. Not for human or veterinary use.
Research overview
About TB-500
TB-500 (Thymosin Beta-4 fragment) is a synthetic peptide that mimics a naturally occurring protein involved in actin regulation and tissue repair.
It promotes cell migration, differentiation, and wound healing by facilitating actin polymerization and angiogenesis. In research models, TB-500 is studied for its systemic effects on tissue regeneration, flexibility, inflammation reduction, and recovery from muscle, tendon, and ligament injuries.
Key Research Areas
- Tissue repair and regeneration (muscles, tendons, ligaments)
- Wound healing and injury recovery
- Actin regulation and cell migration
- Anti-inflammatory effects
- Cardiovascular and systemic recovery models
Storage Requirements
Stability Information
Protect from light
- Lyophilized (powder)
- -20°C · stable long-term
- Reconstituted
- 2-8°C · use within 14-30 days · Avoid · Repeated freeze-thaw cycles
Sources & references10 peer-reviewed publications and databases
Expert Opinion on Biological Therapy
Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications
Goldstein AL, Hannappel E, Sosne G, Kleinman HK
2012 · DOI: 10.1517/14712598.2012.634793 · PMID: 22074294
Annals of the New York Academy of Sciences
Ruff D, Crockford D, Girardi G, Zhang Y
2010 · DOI: 10.1111/j.1749-6632.2010.05474.x · PMID: 20536472
Journal of the Neurological Sciences
A Dose Response Study of Thymosin β4 for the Treatment of Acute Stroke
Morris DC, Cui Y, Cheung WL, Lu M, Zhang L, Zhang ZG, Chopp M
2014 · DOI: 10.1016/j.jns.2014.07.006 · PMID: 25060418
Journal of Investigative Dermatology
Thymosin beta4 accelerates wound healing
Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK
1999 · DOI: 10.1046/j.1523-1747.1999.00708.x · PMID: 10469335
International Journal of Molecular Sciences (PMC)
Progress on the Function and Application of Thymosin β4
Xing Y, et al.
2021 · DOI: 10.3390/ijms222413136
Nature
Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D
2004 · DOI: 10.1038/nature03000 · PMID: 15565145
Clinical Ophthalmology
Sosne G, Ousler GW
2015 · DOI: 10.2147/OPTH.S80954 · PMID: 26056426
Neuroscience
Thymosin beta4 improves functional neurological outcome in a rat model of embolic stroke
Morris DC, Chopp M, Zhang L, Lu M, Zhang ZG
2010 · DOI: 10.1016/j.neuroscience.2010.05.017 · PMID: 20627173
Journal of Neurosurgery
Treatment of traumatic brain injury with thymosin beta4 in rats
Xiong Y, Mahmood A, Meng Y, Zhang Y, Zhang ZG, Morris DC, Chopp M
2010 · DOI: 10.3171/2010.4.JNS10118 · PMID: 20486893
Nature
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization
Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR
2007 · DOI: 10.1038/nature05383 · PMID: 17108969
Research summaries and references are drawn from published, peer-reviewed literature and are provided for educational reference only. They are not product claims or medical advice. This product is sold strictly for laboratory research and is not for human or veterinary use.
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