Research Peptides

Semax

Name: Semax
Brand: Riptide Peptides
Availability: OutOfStock

≥99% purityLyophilized powderThird-party COA

Semax is supplied as a sterile lyophilized powder in a sealed glass vial, manufactured to ≥99% purity. Every batch is verified by independent third-party analysis and ships with a Certificate of Analysis.

$29.99

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✓ Third-party tested batch
✓ COA available

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Certificate of analysis

The report for the current batch is available on request. Request it here.

⚠ Research use only. This product is intended solely for in-vitro laboratory research by qualified professionals. Not for human or veterinary use.

Research overview

About Semax

Semax is a synthetic heptapeptide analog of the adrenocorticotropic hormone (ACTH 4-10) fragment.

It is primarily researched for its potent nootropic and neuroprotective properties. Semax is studied for its ability to enhance cognitive function, improve memory and learning, support neuroplasticity, modulate BDNF (brain-derived neurotrophic factor) expression, and provide protective effects against various forms of brain stress and damage.

Key Research Areas

Cognitive enhancement and memory improvement
Neuroprotection and brain injury recovery models
Neuroplasticity and BDNF regulation
Stress resilience and anxiety-related models
Focus, mental performance, and stroke recovery studies

Molecular Profile

What Is Semax?

Synthetic heptapeptide analog of ACTH (4-10) with C-terminal Pro-Gly-Pro extension for enhanced stability

Heptapeptide ACTH Analog

Type: Synthetic heptapeptide
CAS Number: 80714-61-0
Molecular Formula: C37H51N9O10S
Molecular Weight: 813.9 g/mol
Amino Acids: 7 residues
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro

PubChem record →

Storage Requirements

Stability Information

Handle with care to maintain potency

Light sensitiveTemperature sensitive

Lyophilized (powder): -20°C · protect from light
Reconstituted: 2-8°C · use within 4 weeks
Nasal spray: 2-8°C · 30 days after opening

Sources & references7 peer-reviewed publications and databases

Brain Research
Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
Dolotov OV, Karpenko EA, Inozemtseva LS, et al.
2006 · DOI: 10.1016/j.brainres.2006.07.108 · PMID: 16996037
BMC Genomics
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia
Medvedeva EV, Dmitrieva VG, Povarova OV, et al.
2014 · DOI: 10.1186/1471-2164-15-228 · PMID: 24661656
Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
The efficacy of semax in the treatment of patients at different stages of ischemic stroke
2018 · PMID: 29798983
Journal of Molecular Neuroscience
Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action
Shadrina M, Kolomin T, Agapova T, et al.
2010 · DOI: 10.1007/s12031-009-9270-z · PMID: 19662538
International Journal of Molecular Sciences
Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Molecular Level
2020 · PMID: 32575851
Alzheimer’s Drug Discovery Foundation
Semax – Cognitive Vitality For Researchers
PubChem Database
Semax – Compound Summary (CID 9811102)

Research summaries and references are drawn from published, peer-reviewed literature and are provided for educational reference only. They are not product claims or medical advice. This product is sold strictly for laboratory research and is not for human or veterinary use.

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