Molecular Profile
What Is MOTS-c?
Cell Metabolism 2015
- Type
- Mitochondrial-derived peptide
- Amino Acids
- 16
- Sequence
- MRWQEMGYIFYPRKLR
- Molecular Weight
- 2,174.6 g/mol
- Formula
- C101H152N28O22S2
- Encoded in
- 12S rRNA (mtDNA)
Research Peptides
MOTS-C
≥99% purityLyophilized powderThird-party COA
MOTS-C is supplied as a sterile lyophilized powder in a sealed glass vial, manufactured to ≥99% purity. Every batch is verified by independent third-party analysis and ships with a Certificate of Analysis.
$39.99
1
- ✓ Same-day dispatch
- ✓ Discreet packaging
- ✓ Third-party tested batch
- ✓ COA available
Certificate of analysis
MOTS-C is supplied as a sterile lyophilized powder in a sealed glass vial, manufactured to ≥99% purity. Every batch is verified by independent third-party analysis and ships with a Certificate of Analysis.
⚠ Research use only. This product is intended solely for in-vitro laboratory research by qualified professionals. Not for human or veterinary use.
Research overview
About MOTS-C
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a 16-amino acid mitochondrial-derived peptide (MDP) encoded directly in the mitochondrial DNA.
It functions as a bioactive signaling molecule that helps regulate metabolic homeostasis. In research models, MOTS-c is studied for its ability to enhance insulin sensitivity, promote fatty acid oxidation, improve mitochondrial function, and mimic some beneficial effects of exercise on metabolism and energy balance.
Key Research Areas
- Metabolic regulation and insulin sensitivity
- Mitochondrial bioenergetics and function
- Exercise mimetic and physical performance models
- Fat metabolism and body composition
- Anti-aging, longevity, and metabolic disorder research
Storage Requirements
Stability Information
Extremely temperature sensitiveStore frozen until use
- Lyophilized (powder)
- -20°C · stable long-term
- Reconstituted
- 2-8°C · use immediately
- Room temperature
- Degrades 85-90% in 2-3 hrs
Sources & references8 peer-reviewed publications and databases
Cell Metabolism
Lee C, Zeng J, Drew BG et al.
2015 · DOI: 10.1016/j.cmet.2015.02.009 · PMID: 25738459
Nature Communications
Reynolds JC, Lai RW, Woodhead JST et al.
2021 · DOI: 10.1038/s41467-020-20790-0
Alzheimer’s Drug Discovery Foundation
MOTS-c Cognitive Vitality Report
2021
Aging Cell
The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?
Fuku N, Pareja-Galeano H, Zempo H et al.
2015 · DOI: 10.1111/acel.12389 · PMID: 26289118
Physiol Rep
Kim S-J, Miller B, Mehta HH et al.
2019 · PMID: 31293078
Biochemical and Biophysical Research Communications
Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation
Ming W, Lu G, Xin S et al.
2016
Pediatric Diabetes
Du C, Zhang C, Wu W et al.
2018
ClinicalTrials.gov
Study of CB4211 in Patients With Nonalcoholic Fatty Liver Disease (NAFLD) and Obesity
2019
Research summaries and references are drawn from published, peer-reviewed literature and are provided for educational reference only. They are not product claims or medical advice. This product is sold strictly for laboratory research and is not for human or veterinary use.
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