Molecular Profile
What Is KPV?
- Type
- Synthetic tripeptide
- Sequence
- Lys-Pro-Val (KPV)
- Amino acids
- 3
- Molecular formula
- C₁₆H₃₀N₄O₄
- Molecular weight
- 342.43 g/mol
- CAS Number
- 67727-97-3
- Origin
- α-MSH residues 11-13
Research Peptides
KPV
≥99% purityLyophilized powderThird-party COA
KPV is supplied as a sterile lyophilized powder in a sealed glass vial, manufactured to ≥99% purity. Every batch is verified by independent third-party analysis and ships with a Certificate of Analysis.
$39.99
1
- ✓ Same-day dispatch
- ✓ Discreet packaging
- ✓ Third-party tested batch
- ✓ COA available
Certificate of analysis
KPV is supplied as a sterile lyophilized powder in a sealed glass vial, manufactured to ≥99% purity. Every batch is verified by independent third-party analysis and ships with a Certificate of Analysis.
⚠ Research use only. This product is intended solely for in-vitro laboratory research by qualified professionals. Not for human or veterinary use.
Research overview
About KPV
KPV (Lys-Pro-Val) is a synthetic tripeptide derived from the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH).
It is known for its potent anti-inflammatory properties, acting independently of melanocortin receptors by modulating NF-κB signaling and reducing pro-inflammatory cytokine production. In research models, KPV is studied for its ability to support gut barrier integrity, promote tissue healing, reduce intestinal inflammation, and provide benefits in dermatological and systemic inflammatory conditions.
Key Research Areas
- Anti-inflammatory and immunomodulatory effects
- Gastrointestinal health and IBD models
- Skin repair, wound healing, and dermatological applications
- Cytokine regulation and oxidative stress
- Tissue protection and recovery studies
Parent Compound
Relationship to α-MSH
Br J Pharmacol Review
- Parent peptide
- α-Melanocyte-Stimulating Hormone
- α-MSH length
- 13 amino acids
- KPV position
- C-terminal (11-13)
- Activity retained
- Anti-inflammatory effects
- MCR binding
- NOT required for activity
Storage Requirements
Stability Information
Freeze for storageRefrigerate after reconstitutionProtect from light
- Lyophilized (powder)
- -20°C long-term
- Reconstituted
- 2-8°C · use within 7 days
- Light protection
- Store away from light
Sources & references4 peer-reviewed publications and databases
Gastroenterology
PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation
Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al.
2008 · DOI: 10.1053/j.gastro.2007.10.026 · PMID: 18061177
British Journal of Pharmacology
α-MSH Related Peptides: A New Class of Anti-Inflammatory and Immunomodulating Drugs
Luger TA, Brzoska T, Scholzen TE, et al.
2000 · DOI: 10.1111/j.1476-5381.2000.00178.x
Molecular Pharmaceutics
Xiao B, Xu Z, Viennois E, et al.
2017 · PMID: 28548842
Annals of the New York Academy of Sciences
Kannengiesser K, Maaser C, Heidemann J, et al.
2008 · PMID: 18226903
Research summaries and references are drawn from published, peer-reviewed literature and are provided for educational reference only. They are not product claims or medical advice. This product is sold strictly for laboratory research and is not for human or veterinary use.
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