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MOTS-C

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Research Applications

Designed for precision research, these peptides support a wide range of experimental protocols. Ideal for laboratory studies requiring consistent, reproducible compound delivery.

Safety & Compliance

All products are intended for research use only. Follow standard lab safety guidelines, including proper protective equipment and waste disposal protocols.

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a 16-amino acid mitochondrial-derived peptide (MDP) encoded directly in the mitochondrial DNA.

It functions as a bioactive signaling molecule that helps regulate metabolic homeostasis. In research models, MOTS-c is studied for its ability to enhance insulin sensitivity, promote fatty acid oxidation, improve mitochondrial function, and mimic some beneficial effects of exercise on metabolism and energy balance.

Key Research Areas:

  • Metabolic regulation and insulin sensitivity
  • Mitochondrial bioenergetics and function
  • Exercise mimetic and physical performance models
  • Fat metabolism and body composition
  • Anti-aging, longevity, and metabolic disorder research

Compound Information🧪

Technical specifications

Molecular Profile

What Is MOTS-c?

Type Mitochondrial-derived peptide
Amino Acids 16
Sequence MRWQEMGYIFYPRKLR
Molecular Weight 2,174.6 g/mol
Formula C101H152N28O22S2
Encoded in 12S rRNA (mtDNA)

Cell Metabolism 2015

Storage Requirements

Stability Information

Extremely temperature sensitive
❄️ Store frozen until use
Lyophilized (powder)
❄️ -20°C • stable long-term
💉Reconstituted
2-8°C • use immediately
❄️Room temperature
Degrades 85-90% in 2-3 hrs

📚Sources & References

Cell Metabolism

Cell Metabolism

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

2015•DOI: 10.1016/j.cmet.2015.02.009•PMID: 25738459

Lee C, Zeng J, Drew BG et al.

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Nature Communications

Nature Communications

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

2021•DOI: 10.1038/s41467-020-20790-0

Reynolds JC, Lai RW, Woodhead JST et al.

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Alzheimer's Drug Discovery Foundation

Alzheimer's Drug Discovery Foundation

MOTS-c Cognitive Vitality Report

2021

ADDF Aging and Alzheimer's Prevention Program

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Aging Cell

Aging Cell

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

2015•DOI: 10.1111/acel.12389•PMID: 26289118

Fuku N, Pareja-Galeano H, Zempo H et al.

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Physiol Rep

Physiol Rep

The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity

2019•PMID: 31293078

Kim S-J, Miller B, Mehta HH et al.

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Biochemical and Biophysical Research Communications

Biochemical and Biophysical Research Communications

Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation

2016

Ming W, Lu G, Xin S et al.

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Pediatric Diabetes

Pediatric Diabetes

Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance

2018

Du C, Zhang C, Wu W et al.

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ClinicalTrials.gov

ClinicalTrials.gov

Study of CB4211 in Patients With Nonalcoholic Fatty Liver Disease (NAFLD) and Obesity

2019

CohBar, Inc.

View Source

⚠️Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

Weight.4 oz
Dimensions.6 × .6 × 1.4 in
Size10mg, 40mg

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All products offered on our website are accompanied by a Certificate of Analysis (COA) to ensure quality, purity, and consistency for research purposes.

Each batch undergoes rigorous analytical testing performed by qualified laboratories using validated methods such as High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). These tests verify the identity, purity, and composition of the product.

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